Publications

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2019

Hadley DJ. and Silva EA. Thaw-Induced Gelation of Alginate Hydrogels for Versatile Delivery of Therapeutics. Annals of Biomedical Engineering  2019 May. (PubMed PMID: 31044339) (Impact Factor= 3.405)

Madrigal JL*, Shams S*, Stilhano RS and Silva EA.  Characterizing the encapsulation and release of lentivectors and adeno-associated vectors from degradable alginate hydrogels. Biomaterials Science 2019 Jan 29;7(2):645-656. (PubMed PMID: 30534722) (Impact Factor= 5.831) (* authors contributed equally to this work)


2018

Campbell KT, Stilhano RS and Silva EA.  Enzymatically degradable alginate hydrogel systems to deliver endothelial progenitor cells for potential revasculature applications. Biomaterials  2018 Oct;179:109-121. (PubMed PMID: 29980073) (Impact Factor= 8.806)

Madrigal JL, Sharma SN, Campbell KT, Stilhano RS, Gijsbers R, Silva EA. Microgels produced using microfluidic on-chip polymer blending for controlled released of VEGF encoding lentivectors. Acta Biomaterialia  2018 Mar 15;69:265-276.(PubMed PMID: 29398644) (Impact Factor= 6.383)

Torres AL, Bidarra SJ, Pinto MT, Aguiar PC, Silva EA.#, Barrias C.C.# Guiding morphogenesis in cell-instructive microgels for therapeutic angiogenesis. Biomaterials Volume 154, February 2018, Pages 34–47 (# co-senior and co-corresponding author) (PubMed PMID: 29120817) (Impact Factor8.806)

Williams PA, Campbell KT, Silva EA. Alginate hydrogels of varied molecular weight distribution enable sustained release of sphingosine-1-phosphate and promote angiogenesis. Journal of Biomedical Materials Research Part A  2018; 106(1):138-146. (Pubmed PMID: 28875559) (Impact Factor3.231)


2017

Madrigal JL, Stilhano RS, Silva EA. Biomaterial Guided Gene Delivery for Musculoskeletal Tissue Repair. Tissue Engineering Part B: Reviews 2017; 23(4):347-361.(doi:10.1089/ten.TEB.2016.0462) (Pubmed PMID: 28166711) (Impact Factor3.892)

Williams PA, Campbell KT, Gharaviram H, Madrigal JL, Silva EA. Alginate-chitosan hydrogels provide a sustained gradient of sphingosine-1-phosphate for therapeutic angiogenesis. Ann Biomed Eng.  2017; 45(4):1003-1014. (Pubmed PMID: 27904998)(Impact Factor= 2.887)

Campbell KT, Hadley DJ, Kukis DL, Silva EA. Alginate hydrogels allow for bioactive and sustained release of VEGF-C and VEGF-D for lymphangiogenic therapeutic applications. PLoS One. 2017 Jul 19;12(7):e0181484. (pdf) (Pubmed PMID:28723974)

Anderson EM*, Silva EA*, Hao Y, Martinick KD, Lewin SA, Stafford AG, Doherty EG, Wang L, Doherty EJ, Grossman PM#, Mooney DJ#. VEGF and IGF delivered from alginate hydrogels promotes stable perfusion recovery in ischemic hindlimbs of aged mice and rabbits. Journal of Vascular Research 2017 54(5):288-298 (* authors contributed equally to this work) (# co-corresponding author) (Pubmed PMID: 28930755)


2016

Orbay H, Devi K, Williams PA, Dehghani T, Silva EA, Sahar DE. Comparison of Endothelial Differentiation Capacities of Human and Rat Adipose-Derived Stem Cells. Plast Reconstr Surg. 2016 Dec;138(6):1231-1241. PMID: 27879591 (Impact Factor = 3.087)

Madrigal JL, Stilhano RS, Siltanen C, Tanaka K, Rezvani S, Morgan R, Revzin A, Han SH,  Silva EA. Microfluidic generation of alginate microgels for the controlled delivery of lentivectors. Journal of Materials Chemistry B 2016,4, 6989-6999(10.1039/C6TB02150F) (Impact Factor4.872)

Stilhano RS*, Madrigal JL*, Wong K, Williams PA, Martin PKM,  Yamaguchi FSM, Samoto VY, Han SH, Silva EA.  Injectable alginate hydrogel for enhanced spatiotemporal control of lentivector delivery in murine skeletal muscle. (*authors contributed equally to this work) Journal of Controlled Release 2016 Sep 10;237:42-9. doi: 10.1016/j.jconrel.2016.06.047. Epub 2016 Jul 1. (doi:10.1016/j.jconrel.2016.06.047) PMID: 27374631 (Impact Factor= 7.441)

Murphy KC, Stilhano RS, Mitra D, Zhou D, Batarni S, Silva EA, Leach JK. Hydrogel biophysical properties instruct coculture-mediated osteogenic potential. FASEB J. 2016; 30(1):477-86. PMID: 26443826 (Impact Factor= 5.299)


2015

Williams PA and Silva EA. The Role of Synthetic Extracellular Matrices in Endothelial Progenitor Cell Homing for Treatment of Vascular Disease. Ann Biomed Eng. 2015 Jul 24. PMID: 26206680 (Impact Factor= 2.887)

Binder BY*, Williams PA*, Silva EA#, Leach JK#. Lysophosphatidic Acid and Sphingosine-1-phosphate: A Concise Review of Biological Function and Applications for Tissue Engineering. Tissue Eng Part B Rev. 2015 Jun 2. [Epub ahead of print] PMID: 26035484 (* authors contributed equally to this work) (# co-corresponding authors) (Impact Factor= 3.892)

Tellechea A, Silva EA, Min J, Leal EC, Auster ME, Pradhan-Nabzdyk L, Shih W, Mooney DJ, Veves A. Alginate and DNA Gels Are Suitable Delivery Systems for Diabetic Wound Healing. Int J Low Extrem Wounds. 2015 Jun;14(2):146-53. PMID: 26032947 (Impact Factor= 1.366)

Williams PA, Stilhano RS, To VP, Tran L, Wong K, Silva EA. Hypoxia Augments Outgrowth Endothelial Cell (OEC) Sprouting and Directed Migration in Response to Sphingosine-1-Phosphate (S1P). PLoS ONE. 2015 Apr 15; 10(4): e0123437. PMID: 25875493 (Impact Factor4.17)


2014

Brudno Y*, Silva EA*, Kearney CJ, Lewin SA, Miller A, Martinick KD, Aizenberg M, Mooney DJ (2014). “Refilling drug delivery depots through the blood.” Proc Natl Acad Sci U S A. 111(35): 12722-12727. (*contributed equally to this work) (Impact Factor= 9.423) (This work is featured as an Editor’s Choice in Science 345 (6202):1308 (2014). This work is featured in a Science and Technology Concentrate in C&E News92(34):22 (2014) .  This work is featured in a feature on Medical Research News in MedicalXpress . This work was also  featured in an article in News and Views in Nature Nanotechnology. This work was featured in the News and Analysis section in the Materials Research Society Bulletin.)

Silva EA, Eseonu C, Mooney DJ. Endothelial cells expressing low levels of CD143 (ACE) exhibit enhanced sprouting and potency in relieving tissue ischemia. Angiogenesis. 2014 Jul;17(3):617-30. (Impact Factor= 4.301)

Fonseca KB, Gomes DB, Lee K, Santos SG, Sousa A, Silva EA, Mooney DJ, Granja PL, Barrias CC. Injectable MMP-Sensitive Alginate Hydrogels as hMSC Delivery Systems. Biomacromolecules. 2014 Jan 13;15(1):380-90. (Impact Factor= 5.583)


2013

Shamis Y, Silva EA, Hewitt KJ, Brudno Y, Levenberg S, Mooney DJ, Garlick JA. Fibroblasts derived from human pluripotent stem cells activate angiogenic responses in vitro and in vivo. PLoS ONE. 2013 Dec 30;8(12):e83755 (Impact Factor4.17)

Lui KO, Zangi L, Silva EA, Bu L, Sahara M, Li RA, Mooney DJ, Chien KR. Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA. Cell Res. 2013 Oct;23(10):1172-1186. (Impact Factor14.812)

Kaigler D, Silva EA, Mooney DJ. “Guided Bone Regeneration (GBR) Utilizing Injectable Vascular Endothelial Growth Factor (VEGF) Delivery Gel.” J Periodontol. 2013 Feb;84(2):230-8


2012

Kodiyan A, Silva EA, Kim J, Aizenberg M, Mooney DJ. “Surface modification with alginate-derived polymers for stable, protein-repellent, long-circulating gold nanoparticles.” ACS Nano. 2012 Jun 26;6(6): 4796-805. (Impact Factor13.334)


selected publications before 2012

Vacharathit V, Silva EA, Mooney DJ. “Viability and Functionality of Cells Delivered from Peptide Conjugated Scaffolds” Biomaterials. 2011 May; 32(15): 3721-8  (Impact Factor8.387)

Kim J, Cao L, Shvartsman D, Silva EA, Mooney DJ. “Targeted Delivery of Nanoparticles to Ischemic Muscle for Imaging and Therapeutic Angiogenesis.” Nano Lett. 2011 Feb 9; 11(2): 694-700 (Impact Factor13.779)

Yuen WW, Du NR, Chan CH, Silva EA, Mooney DJ. “Mimicking nature by codelivery of stimulant and inhibitor to create temporally stable and spatially restricted angiogenic zones.” Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17933-8.  (Impact Factor9.423)

Lee K, Silva EA, Mooney DJ. “Growth factor delivery-based tissue engineering: general approaches and a review of recent developments.” J R Soc Interface. 2011 Feb 6;8(55): 155-70  (Impact Factor3.917)

Sun Q, Silva EA, Wang A, Fritton JC, Mooney DJ, Schaffler MB, Grossman PM, Rajagopalan S. “Sustained Release of Multiple Growth Factors from Injectable Polymeric System as a Novel Therapeutic Approach Towards Angiogenesis.” Pharm Res. 2010 Feb;27(2):264-71  (Impact Factor3.42)

Silva EA, Mooney DJ. “Effects of VEGF temporal and spatial presentation on angiogenesis.” Biomaterials 2010 Feb; 31(6): 1235-41.  (Impact Factor8.387)

Silva EA, Suk E, Kong H, Mooney DJ. “Material-based deployment enhances efficacy of endothelial progenitor cells.” Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14347-52.  (Impact Factor= 9.423)

Chen RR, Silva EA, Yuen WW, Brock AA, Fischbach C, Lin AS, Guldberg RE, Mooney DJ. “Integrated approach to designing growth factor delivery systems.” FASEB J. 2007 Dec;21(14):3896-903.  (Impact Factor= 5.299)

Hao X, Silva EA, Mansson-Broberg A, Grinnemo KH, Siddiqui AJ, Dellgren G, Wardell E, Brodin LA, Mooney DJ, Sylven C. “Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction.” Cardiovasc Res. 2007 Jul 1;75(1):178-85.  (Impact Factor5.815)

Mooney DJ, Silva EA. “Tissue engineering: a glue for biomaterials.” Nat Mater. 2007 May;6(5):327-8.  (Impact Factor= 38.891)

Silva EA, Mooney DJ. “Spatiotemporal control of vascular endothelial growth factor delivery from injectable hydrogels enhances angiogenesis.” J Thromb Haemost. 2007 Mar;5(3):590-8.  (Impact Factor5.565)

Chen RR, Silva EA, Yuen WW, Mooney DJ. “Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation.” Pharm Res. 2007 Feb;24(2):258-64.  (Impact Factor3.42)


Patents:

US patent Ref. 13/582,900 (Sept. 2012): “Enhancement of Skeletal Muscle Stem Cell Engraftment by Dual Delivery of VEGF and IGF-1”

US provisional patent application (Feb. 2014): “Refillable drug delivery devices and methods of use thereof”

US patent filed (filed on Dec. 2011): “Conditioned medium and uses in healing injured tissue”

US patent filed (filed on Sep. 2011): “Use of alginate-derived polymers for stable, long-circulating nanoparticles”


US Patent Ref. 61/230,169: “In situ programming of dendritic cells for tolerogenic therapies”

US and European Patent Ref. 29297-014: “Scaffolds for Cell Transplantation”

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